As a part of our studies to develop anticancer agents with prolonged action and reduced side effects, we examined the macromolecular complex of doxorubicin and heparin. Formation of a complex of doxorubicin and heparin was confirmed by HIAC, infrared, ultraviolet, differential scanning calorimetry, energy micro analysis X-ray and high performance liquid chromatography analysis. If the molecular weight of heparin is assumed to be 9800, one molecule of heparin binds 16 molecules of doxorubicin.

A case of fibrosarcoma arising in the scar of the radical mastectomy with postoperative irradiation of breast carcinoma is reported. The tumors arose five times in spite of the extirpations including surrounding tissue since 11 years after radical mastectomy and postoperative irradiation. All of arisen tumors were diagnosed fibrosarcoma histologically and with every recurrence the aggravation of malignancy of tumors was shown. In this case, the primary tumor of the breast was infiltrating carcinoma and no sign of fibrosarcoma was noted histologically. The mastectomy scar was indicated the irradiation therapy postoperatively and fibrosarcoma developed 11 years after postoperative irradiation. Namely, this case agreed to the strict criteria of the postirradiation sarcoma proposed by Cahan et al. In this paper, a case of postirradiation fibrosarcoma arising in the scar of radical mastectomy for carcinoma is presented.

Intrahepatic pigment calculi are frequently found in East Asia and are associated with a considerable morbidity and mortality. The various methods of surgical treatment are unsatisfactory. A wraparound end-to-end hepaticojejunostomy presented may provide an effective and alternative method of treatment.

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