No abstract

No abstract

CIO-,. 7. Restoration of the GABA depolarization to its control level after augmentation by Cl-injection had a mean time constant of 27-8 + 2-6 min. Picrotoxin did not alter this value.8. When foreign anions were exchanged for Cl-in the perfusion solution, the ten anions smaller or equal to ClO3-, decreased the GABA depolarization by 50-90 % and increased its time course 1-5-20 x control. The only exception having a small radius was Br-which augmented the amplitude 10-30 %.9. The ten anions larger than C103-produced a biphasic effect, i.e. an initial Japan.J. P. GALLAGHER, H. HIGASHI AND S. NISHI augmentation followed by a marked (up to 100 %) depression of the response. Experiments with CH3COO-, CH3S04-, or HOCH2CH2SO3-, indicated that this depression was non-competitive.

1. The possible roles of glycine and y-aminobutyric acid (GABA)

No abstract