SUMMARYIntroduction: This paper draws a research project that aims to understand the psychophysiological gymnastics necessary to cope with the trauma's "pathosplastic gymnastic", elucidating the successful or adaptation magic of resilient individuals. As study justification we point motivation and curiosity to obtain an assertive answer to the question: How and Why individuals exposed to dramatic life events didn't develop PTSD or any psychopathological symptom but reveal their adaptive magic? This answer could not only enlightening protector, vulnerability and risk factors but also if this extraordinary individuals have a singular biology that enable us to find if resilience has a pattern of biomarkers which could provide the interventional tools to promote resilience and prevent breakdown, monitoring psychophysiology of resilience and consequently promote Health and Well-Being.Keywords: Resilience, Prevention, Biomarkers, Pharmacotherapy. PREVIOUS CONSIDERATIONSDefinitely the argument to bring to light the psychophysiology of resilience, it's the potentiality to promote Well-being and provide most effective insight about the extraordinary body of resilient individuals "what are made of" and "how it recovers homeostasis or balances itself" and knowing that exists already in the market oxytocin nasal spray and scientific literature indicates benefits of using it for PTSD (Eidelman-Rothman et al, 2015) and other disorders as autism spectrum, schizophrenia and depression (Barraza et al, 2013), we aim to contribute with this research project to the development of new pharmacotherapy and new benefits of use of those existing.