The article is devoted to the development and use of intelligent systems in the management of medical technological processes and health-related quality of life (HRQOL). The relevance of the work is due to the need for effective use of intelligent systems in healthcare. The purpose of this work is to study the possibilities and prospects of using information technologies and artificial intelligence systems in clinical medicine to improve the efficiency of providing medical care to the population. Information retrieval method; theoretical analysis of legislative and regulatory documents, literary sources, Internet resources, research results; spectral-dynamic and mathematical analysis of the current state and assessment of the quality of life of an individual using the artificial intelligence system "CME". The paper analyzes the development trends of information technologies and artificial intelligence systems, as well as the features of their use in medical technological processes. As an example, the technological capabilities of the intelligent system Complex Medical Expert are briefly described.