ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Synthesis and Hypnotic Activity of Some 2-Thioxo-4,5-imidazolidinedione Derivatives.-The title compounds, e.g. (III), are tested for hypnotic and sedative activity as potentiation of sleeping time induced by pentobarbital. All tested compounds increase the sleeping time significantly.- (OEZKIRIMLI, S.; HAMALI, O.; Farmaco 50 (1995) 1, 65-67; Dep. Pharm. Chem., Fac. Pharm., Univ. Istanbul, TR-34452 Istanbul, Turk.; EN)

Evaluation of Some New 1,3-Disubstituted 2-Thioxo-4,5-Imidazolidinediones as Hypnotic Agents. -The synthesized title compounds (III) and (V) potentiate pentobarbital induced hypnosis in mice. The compound (Vb) exhibits the most potent activity. -(ULUSOY*, N.; GUERSU, E.; OEZKIRIMLI, S.; EKINCI, A. C.; DIKICI, I.; Indian J.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Synthesis and Pharmacology of New Dithiocarbamic Acid EstersDerived from Phenothiazine and Diphenylamine.-Fourteen new esters such as (III) and (V) are synthesized and tested for antihistaminic and anticholinergic activities. The compounds show no significant anticholinergic activity. Esters (IIIc) and (Vc) exhibit moderate antihistaminic activity. In general, diphenylamines (V) are more active than phenothiazines (III). -