The review considers the role of intestinal endotoxin in the pathogenesis of a number of obstetric and gynecological diseases, as well as the results of their treatment with the use of enterosorption in order to correct endotoxin aggression. The well-known methods for determining anti-endotoxin immunity and modern classification of enterosorbents were presented. The analysis of the main results of more than 30 years experience in the use of enterosorbent polymethylsiloxane polyhydrate was conducted, taking into account the mechanisms of its medical and prophylactic effects in the treatment of pre-eclampsia, arterial hypertension of pregnant women, miscarriage, endometriosis, chronic pelvic inflammatory disease, urogenital disorders, vulvar lichen sclerosus. The evaluation of therapeutic properties of the drug polymethylsiloxane polyhydrate was carried out, and prospective directions for its further use in obstetric and gynecological practice were planned. Key words: pregnancy loss, pre-eclampsia, vulvar lichen sclerosus, endometriosis, endotoxin, endotoxin aggression, enterosgel