Vaccines are weakened or dead microbes injected for the development of an acquired immunity as a preventive measure, also including the use of microbial proteins. The spectrum of adverse events following vaccination has been increasing as well with increasing number of reports detailing the events following immunization. The rate of morbidity and mortality of many communicable diseases has significantly decreased with time with relieve to the quality of life as well as the overall pharma economic cost. In this case report vaccine-induced developmental delay was observed in a child of 16 months of age. The child was born with low birth weight despite which the child was administered with hepatitis B vaccine, poliomyelitis vaccine, and bacillus Calmette-Guerin within 24 h of birth. Consecutive clinical outcomes followed throughout the years, which induced a developmental delay in this child. This case clearly signifies the need for more evidence-based implementation for the management of various diseases at secondary care hospitals.