Medicinal plants are the  sources of medicine. To determine the anti-bacterial effect of synthesized silver nanoparticles using Capsicum on Staphylococcus aureus and Klebsiella pneumoniae. The objective of the study was to determine the effect of different concentration extracts of Capsicum  annuum  (red bell pepper, green bell pepper and yellow bell pepper). The extract from Capsicum showed a higher antibacterial activity against  Klebsiella pneumoniae followed by Staphylococcus aureus. The extract had higher percentages of inhibition with increased concentration  of red and yellow bell pepper.