The cross sections of $e^+e^- \rightarrow K^+K^-J/\psi$ at center-of-mass energies from 4.127 to 4.600~GeV are measured based on 15.6 fb$^{-1}$ data collected with the BESIII detector operating at the BEPCII storage ring. Two resonant structures are observed in the line shape of the cross sections. The mass and width of the first structure are measured to be ($4225.3\pm2.3\pm21.5$) MeV and ($72.9\pm6.1\pm30.8$)~MeV, respectively. They are consistent with those of the established $Y(4230)$. The second structure is observed for the first time with a statistical significance greater than 8$\sigma$, denoted as $Y(4500)$. Its mass and width are determined to be ($4484.7\pm13.3\pm24.1$) MeV and ($111.1\pm30.1\pm15.2$) MeV, respectively. The first presented uncertainties are statistical and the second ones are systematic. The product of the electronic partial width with the decay branching fraction $ \Gamma(Y(4230)\to e^+ e^-) \mathcal{B}(Y(4230) \to K^+ K^- J/\psi)$ is reported.Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.

The integrated luminosities of the XYZ data samples collected in 2016--2017 at center-of-mass energies between 4.19 and 4.28 GeV are measured with a precision better than 1% by analyzing large-angle Bhabha scattering events. The integrated luminosities of the data sets collected in 2010--2014 are updated by considering an additional correction related to the detector performance. These results are essential for precision measurements of the production cross sections of the charmonium and charmonium-like states.

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