In modern industrial broiler poultry farming, the issue of combating the uncontrolled use of antibiotics in the process of growing poultry is being actively addressed. Currently, scientists are looking for an alternative solution to the issue of eliminating the use of antibiotics for prophylactic purposes. In this connection, researchers are intensively working on the development of innovative feed additives that can solve the problem with the immunostatus of the organism of poultry grown in conditions of great crowding. The article discloses the data of experimental experience on the use of new innovative lactulose-containing additives of domestic origin "Kumelakt-1" and "Laktuvet-1". Their positive effect on the morpho-biochemical parameters of the blood and the resistance of the poultry organism has been established. This information allows to predict in vivo the indicators of the safety of the poultry population and are indicators of the quality of the products obtained. New lactulose-containing innovative additives as a regulator of intestinal microflora improved the morpho-biochemical blood index and increased the resistance of the poultry organism. Namely: increased on average in I and II experimental groups in comparison with the control group, the hemoglobin index by 9.7%, erythrocytes by 10.8%, hematocrit by 5.6%. An increase in the level of urea in the blood serum was established by 10.4 and 9.7% (P <0.01), glucose - by 6.5 and 4.8 6.1 and 9.0% (P <0.05), phosphorus - by 8.2 and 6.6% (P <0.01), magnesium - by 9.9 and 9.1% (P <0.05), potassium - by 1.3 and 1.6% (P <0.05), iron - by 1.4 and 1.6% (P <0.05), respectively. The indicators of phagocytic activity in the experimental groups were determined, it was found that, on average, this indicator increased by 5.2% (P <0.05).

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Among veterinary drugs and feed additives, antibacterial agents occupy a special place, which are used not only for the prevention and treatment of bacterial diseases, but also as powerful growth stimulants. It is known from numerous publications that antibiotics used in the poultry industry pose a serious threat to human health. This article presents the results of studies of the effectiveness of the feed additive FRA® S12 and dietary supplement “Lactusil”, as an alternative to the antibacterial drug of the class of cephalosporins, when growing broiler chickens. Feed additive FRA® S12 and dietary supplement “Lactusil” had the most significant effect on the meat productivity of chickens in II and III experimental groups in comparison with the antibiotic drug (test I group). The excess in live weight was 3.09 and 2.58%, the slaughter yield - by 0.9 and 0.4%, the weight of the pectoral muscles - by 16 and 10 g, the yield of grade I carcasses - by 6.9 and 6.2% … The level of erythrocytes in the blood of chickens in test groups II and III was higher than in test group I by 19.87 and 15.06%, the hemoglobin concentration - by 6.37 and 5.42%, the hematocrit content - by 3.28 and 2, 83. The results obtained substantiate the possibility of replacing antibiotic drugs when growing broiler chickens with alternative ones: feed additive FRA® S12 and dietary supplement “Lactusil”.

Aim. Study of the effect of new domestic lactulose-containing feed additives on the biological properties and amino acid composition of the protein in broiler chicken meat. Material and Methods. During the research, classical and modern methods were used: zootechnical, biochemical, etc. The methodological basis was the scientific works of domestic and foreign scientists who studied the features of the effect of feed additives on the body of poultry and its productive qualities. The mass fraction of protein was determined by the Kjeldahl method according to GOST 25011-2015, the mass fraction of fat – by the Extractive-weight method according to GOST 23042-2015, the mass fraction of moisture – by the thermogravimetric method using the ELVIZ moisture analyzer, the mass fraction of total ash – GOST 31727-2012 (ISO 936:1998), amino acid composition of pectoral muscles – by capillary electrophoresis (Kapel 105M). Results. As a result of the experiment, it was found that the use of additives No. 1 and No. 2 helps to stabilize the indices of digestibility of nutrients and, as a result, to improve the metabolic process in the body of the bird. It was found that the digestibility coefficient of dry matter in the experimental groups was by 0.91%, crude protein – by 1.68%, crude fat – by 0.79%, nitrogen-free extractable substances – by 1.33% higher than in the control group. Positive dynamics was also noted in the increase in the weight of the gutted carcass in the experimental groups by 5.47 and 4.46% in comparison with the same indicator in the control group. The use of lactulose-containing additives when growing broilers has led to an improvement in the quantitative and qualitative characteristics of the resulting product ("white" meat). An increase is observed in the value of the mass fraction of protein by 0.5 and 0.6%, respectively, in comparison with the mass fraction of protein in the meat of the control group. The studied feed additives balanced the ratio of essential amino acids to replaceable ones. During the experiment, it was found that in the white meat of the experimental groups, in comparison with the white meat of the control group of broiler chickens, there was an increase in the content of essential amino acids on average by 0.31 г/100 г (3.6%) и 0.41 г/100 г (4.7%), respectively. Conclusion. In terms of a set of indicators, the meat of broiler chickens grown with the use of new lactulose-containing additives No. 1 and No. 2 has higher indicators of meat quality compared to the control. New domestic prebiotic supplements based on lactulose No. 1 and No. 2, used in the experiment, are not only a natural alternative to antibiotics, hormones or other growth stimulants, but also a mechanism for a better approach to the formation of general beneficial physical and biochemical properties of meat of broiler chickens. Given this, these additives can be recommended for widespread implementation in poultry farming.