The purpose of the study is to prove the need for development of innovative territorial clusters (ITC) in steppe regions. With a well-known determination of the factors of sustainable economic development of steppe regions of Russia, territorial planning and formation of environmental management structures were considered the most important. Today, the greatest relevance for steppe regions of Russia should be seen in development of the ITC as the most important condition for transition to a new technological order in the coming decades of the 21th century and a new management system based on improving scenario forecasting tools that allow identifying trends and incentives for sustainable economic development of steppe regions of Russia as a result of minimizing problems and strengthening their economic potential in the process of climate restructuring of the Earth. The results of the study include the following: definition of the ITC role as a tool for normalizing economic relations between research and educational organizations, business, development institutions and the state, as well as possibility of adapting the resulting cluster model of joint activity management to solving problems of sustainable economic development of steppe regions in the context of digital transformation of Russian economy. Innovative territorial approach should become the basis for Complex programs of ecological, economic and noospheric development of Russian regions. And there are all the prerequisites for this-rapid development of digital technologies, and along with it the growth and rapid promotion of digital innovations, without which there is no future, make this goal feasible and achievable. Therefore, it can be said that ITCs in steppe regions should serve as a source of digital innovations in Russian economy, creating new jobs for population, increasing viability of their territories and ensuring food security of the country as a whole.