Матеріали і методи. Антибактерійна стійкість електрозварного з’єднання (ЕЗ) досліджена в умовах гнійно–некротичного ураження, бактеріального забруднення, параканкрозного запалення або наявності калу у міжкишковому анастомозі (МКА), в судинах діаметром до 10 мм, міхуровій протоці діаметром до 12 мм, анальній нориці діаметром до 5 мм. В експерименті на 17 свинях, маса тіла 45 – 75 кг, та в клініці у 74 хворих віком від 24 до 72 років використовували апарати ЕК–300М1 і ЕКВЗ–300 ПатонмедТМ. Результати. У строки спостереження до 30 діб неспроможність ЕЗ у відкритій рані, черевній порожнині, відхіднику не спостерігали. Виявлені E. coli (3 штами), E. faecalis, E. cloacae, C. hofmanii, S. aureus в концентрації до 108, патогенні штами Clostridium у 3 хворих. Відзначене утворення цілісної структури біологічної тканини по всій лінії створення ЕЗ. Вже на 4–ту добу в МКА виявляли новоутворену грануляційну тканину з судинами, продуктивне запалення. Висновки. ЕЗ є суцільним, зберігає просторову структуру залучених волокон, не містить вільних клітинних фрагментів, що є тригерами запалення та поживними речовинами, забезпечує первинне загоєння у присутності мікроорганізмів з лізуючими властивостями.

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The paper gives a description of an all-purpose laboratory complex for investigations of biological tissue behaviour at application of high-frequency currents to them under the conditions, corresponding to welding live tissues by different algorithms. This complex allows studying the influence of various design features of the instruments and welding process parameters on the behaviour and structural changes of biological tissues. This equipment is optimal to conduct optimization of new technological procedures, parameters and software, oriented towards specific surgical procedures. Given as an example are the results of experiments on welding the walls of pig stomach and small intestine at pulsed and continuous feeding of 440 kHz voltage under the conditions corresponding to electric welding of biological tissues. K e y w o r d s : high-frequency welding, biological tissues, all-purpose testing bench, welding algorithms, biological tissue structuresFurther development of technology and equipment for high-frequency welding of biological tissues, which is becoming ever wider applied in medical practice [1][2][3][4][5][6][7], is inseparably linked to comprehensive studies of the influence of various process parameters on behaviour and structural changes of these tissues, which form the welded joint at high-frequency (HF) current passing through them.To conduct this research series, the authors developed a specialized complex (Figure 1), which allows studying under laboratory conditions at minimum cost the regularities of HF current passage, depending on biological tissue type, as well as behaviour of various types of tissues at HF current passage through them by the most diverse algorithms. This complex allows studying the influence of various design features and process parameters, such as, for instance, material, shape, dimensions and weight of electrodes, specific pressure at variable energy parameters of the welding process, etc., on behaviour and structural changes of biological tissues. This equipment is optimum for refining new technological procedures, parameters and * The following staff of PWI participated in the work:

Background: COVID-19 pandemy brought the risks to interrupt the combined oncological therapy during its stages. Materials and Methods: The trends in patient's habitu es were analyzed. The 5 colorectal, 2 prostates, 1 urine bladder, 1 penile and 1 mammary cancer had been found at ambulatory during COVID-19 quarantine.Weakness duration in all of these patients exceeded 3-7 months, comparatively to similar patients before quarantine period. Only 3 patients come at stage 1-2 disease: with prostate (1), urinary bladder (1) and colon (1) cancer, and 1 patient has colon cancer at stage 3. Other patients come at 4 stage, all complicated. The reason for delay was patient's unwillingness to visit a doctor. Results: One patient was denied of surgery through the bad general status, 9 operated on, four of them by emergency. The common for colorectal cases is trend to avoid the preoperative X-ray therapy and concomitant COVID risks. Any patient was infected with COVID during perioperative period. One patient died because of preoperative cancer complications after urgent surgery. Others preserved wounds, plasty flaps and got conventional chemotherapy. Any local relapse manifestations were observed during 2-7 months. Conclusions: At the time of COVID some cancer patients refrain from intime medical aid for psychological reasons. Trend to escape preoperative X-ray therapy with the aim to avoid concomitant COVID risks, especially concerning complicated psychological background, should be discussed.

Purpose of the study. The diabetes move changes estimate and c-peptidemia and insulinemia levels changes in connection with ileoduodenoplasty. Materials and methods. C-peptiemia and insulinemia were estimated in 45 patients with diabetes mellitus type 2. There were 20 men, 25 women, mean (M ± m) age 27,4 ± 9,5 years. Body mass index was from 23,4 to 61,4 kg/cm 2 . For glycemia correction pill medication use 12 patients, insulin injection 18, first revealed diabetes or insulin resistance with poorly corrected hypertension and cardiac insufficiency of 2 stage have 15 patients. Mean (M ± m) diabetic duration was 15,1 ± 7,7 years. Results. At 3 weeks since surgery glycemia correction by means of metformin was necessary in 6 patients, other do not need any diabetes correction.In terms 1–3, 4–6, 7–21 day, 22 day – 3 months, 3–12 months since surgery mean values of studied hormones declined gradually. In spite of this, declining in hormones level were unproportional one to another, in some patients it increases or changes in inverse mode: raising in insulinemia coincidence with decline in c-peptidemia and vice versa. Conclusion. Performing of ileoduodenoplasty lead to disappear of insulin resistance in few days since surgery.In term 3 weeks since surgery steady compensation of diabetes mellitus 2 type occur. Ambiguous changes in c-peptidemia and insulinemia levels both in early and late terms since surgery already not in equivalence with glycemia point out at its interrelation with other regulators of food consumption. Keywords: diabetes mellitus type 2 surgical compensation, ileoduodenoplasty, c-peptidemia and insulinemia changes.