The primary amide functionality present at the carboxyl terminus in the majority of polypeptide hormones and in many bioactive neuropeptides1 is known2 to be derived from a glycine (Gly) residue at the C-terminus of their Gly extended precursors.3We present here a practical, in vitro model for the terminal amidation reaction using either a serine (Ser) or threonine (Thr)4
SUMMARY:The polymerization of methyl methacrylate (MMA) initiated by a-picolinium-pchlorophenacylide in CCl, at 30, 35, and 40°C for four h was investigated dilatometrically. The orders of reaction with respect to the concentrations of ylide and MMA are 0. bzw. 0,37 * lo-'. Die Ergebnisse wurden als radikalische Polymerisation mit einer initiatorabhangigen ubertragung und einem bimolekularen Abbruch erkl5lrt.
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