Marchiafava-Bignami disease (MBD) is a rare neuro degenerative disease characterized by demyelination of corpus callosum. Clinical diagnosis of MBD is challenging due to its nonspecific neurological manifestations. It's promptly diagnosed by brain Magnetic Resonance Imaging (MRI). Prompt treatment with high dose thiamine could be lifesaving. Here we report a 68 year old male with chronic alcoholism who was diagnosed to have MBD and successfully treated with high doses of intravenous thiamine administration.

Posterior Reversible Encephalopathy Syndrome (PRES) is an acute encephalopathy characterized by headache, altered consciousness, visual symptoms and convulsions.Diagnosis is supported by Magnetic resonance imaging (MRI) of the Brain. Here we report a case of PRES in a 24-year-old-male who showed complete recovery with the control of blood pressure. Finally Post Infectious Glomerular Nephritis (PIGN) was found to be the underlying etiology of hypertension to develop PRES.