Dengue is the most important viral disease transmitted by arthropod vectors. At present, it is known four types of virus serotypes, DEN 1, 2, 3 and 4. Differences in the host susceptibility to infection as well as the severity of disease can not be due only to viral virulence. Variations in immune response as a consequence of polymorphisms in regulatory regions of cytokine genes may have influence on the disease outcome. The aim of this study was to verify the occurrence of associations between cytokine gene polymorphisms and Dengue Fever.