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The toxicity of sterically stabilized doxorubicin-containing "solid" liposomes comprising a mixture of distearoyl analogs of phospatidylcholine and phosphatidylethanol (in a 3 : 2 molar ratio) was evaluated. Upon infusion of the ordinary and liposomal doxorubicin in a total dose of 12 mg/kg, the early loss of mice with implanted ascitic Ehrlich's carcinoma was 100 and 50%, respectively, and the average lifetime of the animals treated with liposomal doxorubicin was 1.6 times longer. In comparison to the ordinary doxorubicin, administration of the liposomal preparation resulted in a lower drop of the body weight (10%) and a smaller decrease in leukocyte number (12%). The results of fluorimetric measurements showed that the accumulation of antibiotic in the cardiac muscle 15 -180 min after infusion of the liposomal doxorubicin was 30 -57% lower than that upon infusion of the ordinary preparation.

No abstract