The influence of means and modes of sanitary-hygienic treatments on the surface condition of medical rubber stoppers based on butyl and halobutyl rubbers used for sealing injection and infusion drugs was investigated using the method of determining the contact wetting angle on a DCAT 21 tensiometer. It has been established that the methods used for sanitary-hygienic processing have a destructive effect on the state of the surface, accompanied by a decrease in the edge angle of wetting (an increase in the hydrophilicity of the surface of the stoppers), which significantly increases the possibility of interaction with the dissolved pharmaceutical substances of drugs.