1 In a double‐blind crossover study, flurbiprofen produced marked relief of pain which was significantly more than with aspirin and placebo in patients suffering from primary dysmenorrhoea. In contrast, there was no significant difference between the relief of pain obtained with aspirin and placebo. 2 The clinician's overall assessment of efficacy also indicated that flurbiprofen produced better response as compared to aspirin and placebo in these patients with dysmenorrhoea. 3 Both flurbiprofen and aspirin did not produce any apparent adverse effects on blood loss during the menstrual period. 4 In conclusion, the analgesic effect of flurbiprofen seen in this trial establishes the therapeutic usefulness of the drug in the treatment of primary dysmenorrhoea.

Aplastic anemia is a hematopoietic stem cell disorder characterized by pancytopenia of the peripheral blood and hypocellular bone marrow. Phenytoin is the most commonly and most widely used anticonvulsant, which is used for the prevention and treatment of generalized seizures, partial seizures, and status epileptics. The main aim of the study is to enlighten the drug-related problem and address such problems to prevent the occurrence of adverse event and optimizing drug therapy. Here, we present a case of a 35-year-old female patient who was admitted with complaints of fever, breathlessness, and lower limb swelling. She is a known case of hypertension and generalized tonic clonic seizures for which was taking tablet amlodipine and tablet phenytoin from 5 and 2 years, respectively, after which the patient developed aplastic anemia.

Both the formulations of paracetamol were clinically and statically equivalent. Paracetamol 1,000 mg SR formulation is noninferior to conventional paracetamol 500 mg tablets.