The aim of the study was to increase dissolution rate of atorvastatin by the use of mesoporous silica SYLOID ® 244 FP. The poorly soluble drug atorvastatin was adsorbed on and/or into SYLOID

Sustained release dosage form is mainly designed for maintaining therapeutic blood or tissue levels of the drug for extended period of time with minimized local or systemic adverse effects. Economy and greater patient compliance are other advantages 1. In recent years, clinical studies on Metformin hydrochloride (MET) have demonstrated that this drug is an effective agent for treatment of diabetes mellitus. It is a widely used antidiabetic from biguanide class. The need for present investigation is because of its availability as a single and combinational dosage form. In present study the comparative dissolution study of three marketed tablet formulations i.e. Dibeta-SR (D) [TORRENT], Glycophage (GF) [FRANCO-INDIAN], Gluformin (GF) [PIRAMAL HC] was being carried out. All the formulations showed excellent drug release profile. The present study gives an idea about its release so that it will be useful for further development concerned with the improvement of patient compliance.