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A new method for the preparation of optically active omeprazole, consisting in asymmetric oxidation of the corresponding sulfide with the use of vanadyl complexes with chiral Schiff bases as the catalysts has been elaborated. The best results of the oxidation were achieved by the use of the combination VO(acac) 2 -2 [{(1S,2S,3R,5S) 3 hydroxymethyl 2,6,6 trimethyl bicyclo[3.1.1]hept 2 ylimino}methyl]phenol-N ethyl N,N diisopropylamine.

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