Background: Aescin or β-escin is the main and active constituent of horse chestnut seed (Aesculus hippocastanum) used for the treatment of inflammatory edema, venous insufficiency and ischemic ulcerations. Aescin has many actions due to induction of endothelial nitric oxide and prostaglandin F2-α production moreover; aescin antagonizes the effect of histamine and 5HT at receptor levels. </P><P> Objective: The aim of the present study was to evaluate the neurobehavioral effects of aescin on normal healthy volunteers. </P><P> Method: A total number of 65 healthy participants with mean age of 21+1.1 years were recruited to study the effects of aescin on the neurobehavioral effects of normal healthy volunteers compared to placebo. The neurobehavioral effects were assessed by psychomotor performances and sensorimotor reaction, cortical arousal and central integrity processes and assessment of memory capacity. Results: Placebo produced insignificant amelioration of TRT and RRT p>0.05, with mild significant effect on MRT p=0.03. Aescin produced a significant effect in the amelioration of psychomotor performances and sensorimotor reaction p=0.0001. Regarding the differential effect of placebo and aescin on the cortical arousal and central integrity processes, placebo illustrated insignificant effect at p>0.05 whereas; aescin showed mild significant effect on Critical Fusion Frequency (CFFA) p<0.05 and highly significant effect on the other parameters p<0.01 except for critical-fusion frequency threshold when aescin illustrated insignificant effect at p>0.05. Aescin illustrated significant acceleration of ІІ-back WMA, ІІІ-back WMA and Second trial Short-Term Memory (STM) at p<0.01 compared to the placebo effect. Conclusion: Short-term therapy with aescin improves the neurobehavioral effects on healthy volunteers.

Objective: Despite that women are becoming active participants and protagonists of the development social, economic, and political process, they still suffer from the distress of violence, and this problem still spread worldwide. Domestic violence against women is studied in the general population, but the violence against women with addicted spouses was little highlighted especially in Iraq, and this study aimed to reveal the rate of violence and to clarify the different types of violence against wives of addicted husbands. Methods: This comparative study was carried in Ibn Rushud psychiatric training hospital in Baghdad, Iraq This study has been done during the time extended from10th April to 20thof December 2020, and conducted on 400 married women,200 of them were women with addicted husbands, and200were women with no addicted husband. The inclusion criteria were married women living with her husband, and those women who voluntarily gave consent were included. Divorced widows and pregnant women are excluded. The questionnaire used was valid and reliable and appropriate to our society's culture furthermore it was used in a similar study done in the neighboring country. Data analysis was performed using SPSS. Descriptive statistics and chi-square, Mann-Whitney U, and Kruskal–Wallis tests, odds ratio (OR), and Kendall's correlation coefficient were used to analyze the data. The overall mean score of violence was 70.47 ± 14.32 for the women with addicted husbands and 42.01 ± 7.50 for women with non-addicted spouses (P < 0.001). The mean score of psychological violence was 40.03 ± 5.03 in women with addicted spouses and 23.40 ± 4.26 in those with non-addicted husbands (P < 0.001). Furthermore, the mean score of physical violence was 23.71 ± 6.24 in women with addicted spouses and 15.50 ±3.76 in those with non-addicted husbands (P < 0.001). Moreover, the mean scores of sexual violence were 3.21 ± 2.11 and 2.92 ± 0.25 in women with and without addicted spouses, respectively (P < 0.001). Finally, the mean scores of financial violence were 2.10±0.94and 1.10 ± 0.23 for women with and without an addicted husband, respectively (P<0.001). Result: The finding confirms the conclusion of other studies and reveals that the overall rate of violence was significantly higher among women with addicted spouses and especially if the spouse abused more than one type of substance.

Aescin or β-escin is the main and active constituent of horse chestnut seed (Aesculus hippocastanum) used for treatment of inflammatory edema, venous insufficiency and ischemic ulcerations. Aescin has many actions due to induction of endothelial nitric oxide and prostaglandin F2-α production moreover; aescin antagonizes the effect of histamine and 5HT at receptor levels the aim of the present study was to evaluate the neurobehavioral effects of aescin on normal healthy volunteers. A total number of 65 healthy participants with mean age of 21+1.1 years were recruited to study the effects of aescin on the neurobehavioral effects of normal healthy volunteers compared to placebo. The neurobehavioral effects were assessed by psychomotor performances and sensorimotor reaction, cortical arousal and central integrity processes and assessment of memory capacity. Placebo produced insignificant amelioration of TRT and RRT p>0.05, with mild significant effect on MRT p=0.03. Aescin produced a significant effect in the amelioration of psychomotor performances and sensorimotor reaction p=0.0001. Regarding the differential effect of placebo and aescin on the cortical arousal and central integrity processes, placebo illustrated insignificant effect p>0.05 whereas; aescin showed mild significant effect on critical fusion frequency (CFFA) p<0.05 and highly significant effect on the other parameters p<0.01 except for critical-fusion frequency threshold when aescin illustrated insignificant effect p>0.05. aescin illustrated significant acceleration of ІІ-back WMA, ІІІ-back WMA and Second trial short term memory (STM) p<0.01 compared to the placebo effect. Conclusion: short term therapy with aescin improves the neurobehavioral effects of healthy volunteers.

Background: Staphylococcus aurous one of the most common pathogen that cause a wide range of infection started by simple skin infection and end by septicemias and high possibility of death. The study aimed to: present study try to evaluate the sensitivity and resistance pattern of staphylococcus aureus against Gentamycin, Cotrimethoprim, Amoxicillin and Cefalexin. Methodology: A 55 isolates of staphylococcus aureus obtained from urine, pleural fluid, joint aspiration, ear, skin, and pus, of indoor and outdoor patient in AL-SADER teaching hospital, AL-Najaf AL-Ashref, Iraq. in a period extended between 9-1-2009- ---8-3-2010. And each isolate was tested for these 4 antibacterial drug . Results: and results showed that Gentamycin has the highest percentage of sensitivity by staphylococcus aureus (34.83%) while Amoxicillin showed the highest percentage of resistance by staphylococcus aureus (30%). Conclusion: Gentamycin was the drug of choice in treatment of staphylococcus aureus infection in al-najaf al-ashref. Recommendation: we recommend further evaluation about antibacterial sensitivity together with college of medicine.