Phenolic compounds regarded as important pharmaceuticals with various biological activities are found in low amounts in microalgae. The objective of this study was to increase the amount of phenolic compounds in Spirulina platensis by a two-step batch mode cultivation. The evaluation of the effect of the sudden shift from low light to high light on phenolic compound production, antioxidant activity, growth, and biomass composition of S. platensis was undertaken. The amount of phenolic compounds was significantly increased by approximately eightfold (p<0.01) by the light treatment. There were also increases in total amounts of carbohydrate, phycocyanin, carotenoid, malondialdehyde, and antioxidant activities while there were significant decreases in total protein amounts (p<0.05). The relationships between antioxidant activities and total amounts of phenolic compounds were significantly correlated at the 99% confidence level (p<0.01) indicating that phenolic compounds were major contributors of antioxidant activities.
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