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<p>Smart manufacturing is characterized by self-organizing manufacturing systems and processes that can respond to dynamic changes. We envision the rapid advancement of smart machines with empathy skills will enable anthropocentric human-machine teams that can maximize human flexibility and wellness at work while maintaining the required manufacturing productivity and stability. In this paper, we present a future-proofing human-machine symbiosis framework that features human centrality, social wellness, and adaptability. The essential technical challenges and methods are discussed in detail.</p>

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