Background: Throughout the twenty-first century, type 2 diabetes mellitus (T2DM) has emerged as a severe worldwide public health concern, with the incidence of the disease growing on an annual basis. T2DM has been linked to abnormalities in glucose, lipid, and protein metabolism, among other things. Diabetes has been related to low vitamin D levels, as have the preventive effects of sufficient vitamin D consumption on the risk of microvascular and macrovascular problems in people with T2DM. In addition to regulating hunger, energy balance, and glucose homeostasis, ghrelin is known to be involved in many other biological functions as well. Aim of the Study: One of the goals of this study is to compare the levels of the hormone ghrelin in patients with type 2 diabetes mellitus before and after they have taken an oral vitamin D supplement of 500 IU. Patients and Methods: From January 1st to March 31st, 2021, a follow-up case study was conducted in Kirkuk Governorate. The study comprised 60 diabetes type 2 patients who were given 5000 IU of vitamin D for two months and then had their serum ghrelin levels checked before and after treatment. The SPSS application was used to examine all of the data. Results: In this study, the mean level of ghrelin was elevated significantly in type two diabetes mellitus before administered vitamin D treatment as compared with type two diabetes mellitus after administered vitamin D treatment at p-value is less than 0.01 Conclusions: It was concluded that vitamin D was an important treatment protocol in management of type two diabetes mellitus