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An efficient and convenient protocol for the synthesis of novel bis[spiro(quinazoline-oxindole)] derivatives by one-pot pseudo five-component condensation of two molecules of isatoic anhydride, two molecules of isatins, and diamines in high yields and very short reaction time is described. This green protocol was catalyzed by Alum as a non-toxic, reusable, inexpensive, and easily available reagent.

A versatile pathway for the synthesis of novel bis(quinazolinon‐4(1H)‐one) derivatives by one‐pot pseudo five‐component condensation of two molecules isatoic anhydrides, two molecules orthoesters, and diamines in high yields and short reaction time is described. The work‐up is easy, and the products are obtained in good‐to‐excellent yields and high purity.

KAl(SO 4)2·12H2O(Alum): An Efficient Catalyst for the Synthesis of Novel Bis[spiro(quinazoline-oxindole)] Derivatives via One-Pot Pseudo Five-Component Reactions. -The applied catalyst can be reused at least for four times. -(MOHAMMADI*, A. A.; TAHERI, S.; ASKARI, S.; AHDENOV, R.; J. Heterocycl. Chem. 52 (2015) 6, 1871-1875, http://dx.

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