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A new series of 4-alkyl/aryl-2-oxo-1-pyrazolyl-1,2-dihydropyridine-3-carbonitriles, pyrazolo[3,4-b]pyridine-5-carbonitriles and pyrido[2,3-d]pyrimidine-6-carbonitriles have been synthesized and tested for their anti-inflammatory and analgesic activities. Among the tested compounds, 3e and 8b exhibited comparable anti-inflammatory activity to the standard (indomethacin). Compounds 5, 7a, and 8b displayed potent analgesic activity. Detailed syntheses, spectroscopic and biological data are reported.

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Moiety. -Design and synthesis of a variety of new quinazoline derivatives containing biologically active thione or azole moieties via reactions of isothiocyanate (I) with appropriate nitrogen nucleophiles are described. Assays for antitumor activity show a significant activity of compound (IIIc) against Ehrlich ascites carcinoma tumor cells. -(GHORAB*, M. M.; BARAKAT, S. E.-S.; SAKER, H. M.; RABO, M. M. A.; Arzneim.-Forsch. 56 (2006) 9, 665-670; Dep.