Background-Although inflammation is presumed to contribute to colonic neoplasia in ulcerative colitis (UC), few studies have directly examined this relationship.

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Background and Purpose-The goal of this study was to evaluate the utility of perfusion-weighted CT (PWCT) in predicting final infarct volume and clinical outcome in patients with acute middle cerebral artery (MCA) stroke. Methods-Twenty-two consecutive patients with MCA stem occlusion who underwent intra-arterial thrombolysis within 6 hours of stroke onset had noncontrast CT and CT angiography with whole-brain PWCT imaging before treatment. Infarct volumes were computed from the initial PWCT and follow-up scans; clinical outcome was measured with the modified Rankin scale. Results-Initial PWCT lesion volumes correlated significantly with final infarct volume (Pϭ0.0002) and clinical outcome (Pϭ0.01). For the 10 patients with complete recanalization, the relationship between initial and final lesion volume was especially strong (R 2 ϭ0.94, PϽ0.0001, slope of regression lineϭ0.92). For those without complete recanalization, there was progression of lesion volume on follow-up imaging (R 2 ϭ0.50, Pϭ0.01, slope of regression lineϭ1.61). All patients with either initial PWCT lesion volumes Ͼ100 mL or no recanalization had poor outcomes (Rankin scores, 4 to 6). Mean admission NIH Stroke Scale scores and mean lesion volumes in the poor outcome group were significantly different compared with the good or fair outcome (Rankin scores, 0 to 3) group (21Ϯ4 versus 17Ϯ5, Pϭ0.05, and 106Ϯ79 versus 29Ϯ37 mL, Pϭ0.01). Patients with initial volumes Ͻ100 mL and partial or complete recanalization all had good (Rankin scores, 0 to 2) or fair (Rankin score, 3) outcomes. Conclusions-Lesion volumes on admission PWCT images approximate final infarct volume for patients with early complete recanalization of MCA stem occlusion. For those without complete recanalization, there is subsequent enlargement of lesion volume on follow-up. Initial PWCT lesion volumes also have predictive value; volumes Ͼ100 mL are associated with a poor clinical outcome. In these highly selected patients, initial PWCT lesion volume was a stronger predictor of clinical outcome than was initial NIH Stroke Scale score.