Myocardial infarction (MI) is a cardiovascular syndrome associated with myocardial ischemia. Percutaneous coronary intervention (PCI) is an effective method for treating myocardial infarction that allows for a short hospital stay and rapid recovery This study aimed to assessment Knowledge and Life-style changes of myocardial infarction Patients after percutaneous coronary intervention. Study design and Methods A descriptive study research design has been utilized. A purposive sample of (100) patients with myocardial infarction who underwent Percutaneous coronary intervention were chosen to be included in the present study. Data were collected from 2nd October, 2020 to 1st April,2021. A close-ended questionnaire of four parts was constructed by the authors to assess the knowledge and life-style changes of myocardial infarction Patients after Percutaneous coronary intervention, a questionnaire including four parts included to achieved this aim. Data were analyzed through SPSS software program Descriptive analysis and inferential. Results The study found that the majority of the sample were males (67%), a high percentage 40% of sample with age group (51-60) years old. Also, the study was found that 60% of patients had fair knowledge regarding heart attack, 61% of patients are moderately active relating to daily physical activity. Conclusion There was some lacking of the necessary basic knowledge about myocardial infarction patients after Percutaneous coronary intervention