Abstract. Accommodating the various requirements from distinct perspectives in e-participation calls for a holistic engineering approach for e-participation systems analysis and design. This paper presents research results towards a reference framework for e-participation projects. An analysis of procedural models for e-participation and enterprise architectures in the context of e-participation shows that a holistic approach is necessary. A sophisticated and holistic engineering approach for e-participation in the form of a reference framework is seen as a solution to support e-participation projects development and implementation. The reference framework consists of different concepts supporting each other: dimensions that build the scope of an e-participation project, a domain meta model, a procedural reference model, and a library with requirements, reference models and building blocks for e-participation.

Purpose: To investigate the association between maternal and social/ economic aspects and mother's knowledge about breastfeeding. Methods:A hospital-based study conducted with 71 postpartum women in hospital bed. Data was collected through questionnaires, one on social/ economic factors and another one on knowledge about breastfeeding.

Several genetic factors seem to be involved in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to analyze whether functional polymorphisms in the promoter region of the MMP-1, -3 and -9 genes were associated with RA. The study population comprises 110 RA patients and 100 healthy controls. The -1607 1G/2G MMP-1, -1171 5A/6A MMP-3, and -1562 C/T MMP-9 polymorphisms were analyzed. The frequency of the 5A allele of MMP-3 gene was significantly higher in the controls when compared with the RA patients (0.45 vs. 0.32, P < 0.01). No significant differences were observed in the allele frequencies for the MMP-1 and -9 polymorphisms between RA patients and controls. Individuals carrying MMP-3 5A allele have significant higher frequency of extra-articular manifestations and rheumatoid nodules than individuals homozygous for 6A allele (P < 0.05). The results presented in this study provide evidence of an association between the MMP-3 gene polymorphism and RA.

OBJETIVO: Verificar o diagnóstico otoneurológico de idosos com tontura e a interferência deste sintoma na qualidade de vida. MÉTODOS: Trata-se de um estudo transversal, realizado com 56 idosos com tontura, com média de idade de 71,2 anos, submetidos à avaliação otoneurológica que envolveu: audiometria tonal, audiometria vocal, imitanciometria, provas de equilíbrio, pesquisa do nistagmo e vertigem de posição e posicionamento e vectoeletronistagmografia. Para avaliar a qualidade de vida, utilizou-se um questionário específico para tontura, o Dizziness Handicap Inventory (DHI), que verifica os efeitos incapacitantes provocados por este distúrbio. RESULTADOS: A tontura rotatória foi referida por 29 pacientes (51,8%), 75% apresentaram alguma queixa auditiva e 69,6% apresentaram audiometria alterada. Os pacientes com queixas vestibulares de tontura posicional apresentaram diferença significativa para o aspecto físico do DHI. Já os pacientes com queixas vestibulares de desequilíbrio apresentaram diferença significativa para os aspectos funcional e emocional. A vectoeletronistagmografia computadorizada esteve alterada em 47 pacientes (83,9%), indicando comprometimento vestibular periférico em todos os casos. No exame pós-calórico, a hiperreflexia foi a alteração mais prevalente e o diagnóstico mais frequente foi o de síndrome Vestibular Periférica Deficitária à Esquerda. Com relação à qualidade de vida, o aspecto funcional apresentou o maior escore médio entre os três aspectos avaliados, e observou-se diferença significativa entre os aspectos funcional e o emocional. CONCLUSÃO: Idosos com tontura apresentam, em sua maioria, alterações na audiometria e na vectoeletronistagmografia, indicando disfunção do sistema cócleo-vestibular; apresentam também qualidade de vida comprometida.

The success of innovative e-participation solutions depends heavily on the organizational planning and the incorporation of such initiatives into the different stages of the policy life-cycle. E-participation often demands to introduce new participation facilities into the traditional processes of policy formulation and decision making. Accommodating the various requirements from distinct perspectives calls for a holistic engineering approach for e-participation systems analysis and design. Enterprise Architectures (EA) have evolved in information systems research as an approach to give guidance in developing complex socio-technical systems. This paper analyzes the application of EA frameworks in the context of e-participation. Eparticipation domain and implementation models are investigated to identify crucial tasks and aspects in e-participation project development and implementation. Related to the tasks identified, two EA frameworks are analyzed: the Zachman Framework and TOGAF. We explain how EA frameworks can support the development and implementation of e-participation projects. Finally, the needs for a reference framework for e-participation are argued and a reference framework is presented.