Baseline and follow-up measurements of cerebral hemodynamics were performed in hypertensive patients by the N 2 O method with a certain time interval. A tendency for some decrease in the CBF was noted, but the difference was not statistically significant. Twelve hypertensive patients suffered from a stroke during the period of observation. The CBF values prior to the stroke varied so widely that there was no predictive value from these measurements. The decrease in CBF in a mild case of cerebral infarction is slight and is followed by little fluctuation. The decrease in a case of moderate severity is marked but returns to normal in two to five months. Clinically severe cases of infarction and hemorrhage are also characterized by a marked decrease in CBF, but this decrease of infarcted cases may be irreversible. A higher incidence of recurrent infarction is noted in those patients in whom recovery of CBF following a stroke is poorest. This is most apparent in those patients suffering a recurrence within one year.

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SF-837 is a new macrolide antibiotic isolated from the culture broth of Streptomyces mycarofaciens nov. sp. Results of the fundamental studies reported so far indicate that its antimicrobial antivity, absorption, distribution and excretion are quite similar to those of other macrolides. This paper describes the clinical results of comparative double-blind studies on SF-837 and kitasamycin in the treatment of respiratory infections such as acute tonsillitis, acute bronchitis and bacterial pneumonia. The satisfactory results were obtained in 61 paptients of 73 in the SF-837 group (83.6%) and in 62 patients of 77 in the kitasamycin group (80.5%). Statistical analysis of the obtained results revealed that there was no significant difference between the two groups. (p<0.05, x2=0.356) Generally, the most frequent side effect of macrolide antibiotics is gastrointestinal disturbance, the patients, therefore, were observed with a special attention to this point. As a result, gastrointestinal disturbances were observed in 6 out of 77 cases in the kitasamycin group and only one out of 73 cases in the SF-837 group. From the above results, SF-837 can be considered to be an effective antibiotic comparative to kitasamycin.

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