No abstract

As for the question why the efficacy of DDS can extend over several diseases of exudative but non-infectious such as Herpes dermatitis, Erythema elevatum diutinum, Impedigo in sublayer of Stratum corneum, Schonlein-Henoch type anaphylactic Purpura, Gougerot-Ruiter type allergic Angitis in corium, and Parapsoriasis by daily dosage of 50-150 mg of DDS could not be explained before Katabira, et al, of Japan dermatological field found out a clue to discovery of its inhibitory effect on Carrageenin-induced rat acute edemas, 2, .

No abstract

The anti leprosy actIvIty of a new quinolone, sparfioxacin, was examined in the nude mouse fo otpad model. By serial dosing (once a day,S or 6 times per week, during the 3rd-5th months postinoculation), 10 mg/kg of sparfloxacin displayed bactericidal-type activity and bacteriostatic activity was present at daily doses of 5 and 2 mg/kg. By intermittent dosing (once a day, twice weekly at daily doses of 10 and 20 mg/kg or once weekly at a daily dose of 30 mg/ kg, during the 3rd-5th months postinoculation), sparfloxacin markedly inhibited the growth of leprosy bacilli with slight remultiplication at later stages. Sparfloxacin seems to be worth studying clinically as a novel antileprosy drug.

No abstract