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Abstract-The effects of morphine, adrenocorticotropic hormone (ACTH) and formalin on plasma corticosterone levels were investigated in the nucleus reticularis gigantocellularis (NRGC)-lesioned rats. ACTH (1.0 U/kg) or formalin (6.4%, 0.2 ml/rat) elevated plasma corticosterone in both sham-lesioned and NRGC-lesioned rats at the same degree, while morphine (10 mg/kg) also elevated plasma corticos terone in sham-lesioned rats, the elevation of which was significantly reduced by NRGC-lesioning.These findings suggest that the NRGC is involved in the cor ticosterone-increasing effect of morphine, but not involved in the effect of ACTH or formalin.

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