First syntheses of sesquiterpene quinones (؊ ؊)-tauranin and (؊ ؊)-BE-40644 which exhibited strong cytotoxicity against several cancer cell lines, were achieved from (8aS)-albicanol obtained by enzymatic optical resolution. By comparison of the sign of specific rotation between synthetic (12bS)-BE-40644 and natural (؊ ؊)-BE-40644, the absolute configurations of natural (؊ ؊)-BE-40644 were determined to be 4aS, 6aS, 12aR, 12bS.
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