Objective: Cold methanolic extract of Suaeda maritima have been considered to screen their biological properties such as analgesic, membrane stabilizing and thrombolytic activity. Although some investigations have previously been reported with this plant, the whole plant was not studied yet to date. In the present study we aimed to investigate in vivo and in vitro bioactivities of Suaeda maritima. Material and Methods:The pharmacological analgesic activity was studied by acetic acid induced writhing method in vivo in a mouse model. Membrane stabilizing activity was assessed by inhibition of haemolysis at hypotonic solution induced condition in vitro, and thrombolytic activity was evaluated by employing Streptokinase as standard in vitro. Results: Extract of Suaeda maritima at a dose of 500 mg/kg body weight showed most significant inhibition of writhing at a rate of 82.25% in mice. Among all the fractions, crude methanol extract (ME) showed maximum effect with a value of 61.01% inhibition of hemolysis at 10 mg/ml dose, when standard acetyl salicylic acid (0. 10 mg/mL) revealed 66.37% inhibition of hemolysis. When clots were treated with 100 µl, moderate clot lysis activity observed with each of the test sample, however highest effect was found at 10 mg/ml dose (49. 13%). Conclusion:The Suaeda maritima extract showed a remarkable analgesic effect on a mouse model and membrane stabilizing and trombolytic activities in vivo models. It may introduce a new dimension in human model in analgesic, membrane stabilizing and antitrombolytic activities.

This Present study was surpassed to investigate the methanolic extracts of Spondias pinnata fruit for anxiolytical activities. S. pinnata is a plant of Anacardiacea family. The methanolic crude extract were screened for anxiolytic activities using hole board test method (***p < 0.001) and elevatedplus maze test method (***p < 0.001) in mice. Test results found 40.25±2.98 times for 400mg/ml extract in hole-board and 152.5±44.78, 147.5±, 9.25±1.79 times in elevated plus maze respectively as comparison with standard. The use of crude extracts of fruits of Spondias pinnata as anxiolytics have been confirmed that the fruits extracts displayed potential anxiolytic activity against mice for head dipping and stay in open and enclosed arms in the study. Various concentrations of extracts were tested and results were expressed in terms of time. In conclusion, the methanol extract of the fruits and plant of Spondias pinnata displayed anxiolytic activity.

Aim: The present study was commenced to investigate the methanolic extracts of Launaea sarmentosa (Willd.) and Bruguiera cylindrical (L.) for antibacterial properties. Launaea sarmentosa (Willd.) is a plant of Asteraceae family while Bruguiera cylindrical (L.) belongs to the family of Rhizophoraceae. Materials and Method:The study was performed by disc diffusion method. Results:Crude methanolic extracts of both Launaea sarmentosa (Willd.) and Bruguiera cylindrical (L.) at various concentration were used for antibacterial screening. The methanolic extracts of Launaea sarmentosa (Willd.) produced good antibacterial activities against gram negative (-ve) bacteria and were resistant against gram positive (+ve) bacteria whereas crude methanolic extracts of Bruguiera cylindrical (L.) were resistant against both gram positive (+ve) and gram negative (-ve) bacteria. Conclusion:Further work especially bioassay-guided fractionation may be avouched in order to isolate and characterize the antibacterial active constituents responsible for the antibacterial property.