Different concentrations of fluoride preparations are being used enormously in dental clinics to prevent dental caries and treat tooth sensitivity. In this study the histological effect of sodium fluoride gel and stannous fluoride gel has been compared on buccal mucosa of albino rats. Material and Methods: This experimental study comprised of 30 Albino rats of average weight 200-250gms which were randomly divided into 3 groups. Out of total 30 rats Control group A was assigned 10 albino rats and rest of the 20 rats were included in experimental groups B and C containing 10 rats each. Animals of group B were topically treated with 0.2% sodium fluoride gel at a dose of 0.5mg/Kg as per body weight on buccal mucosa. The rest of the 10 animals of group C were given 0.4% stannous fluoride gel topically at a dose of 1mg/kg as per bodyweight. Both fluoride gels were applied once daily for 4 minutes with the help of cotton pellet on buccal mucosa for 14 days and were sacrificed on last day under deep anesthesia. Buccal mucosa of each group was taken out for biopsy. The specimens were treated with haematoxylin and eosin stain. Conclusion: Histological analysis showed that sodium fluoride gel has significant toxicity as compared to stannous fluoride gel.

Objective: To evaluate the effect of different preparations of fluoride gels on the salivary pH of albino rats. Material and Methods: This experimental study consisted of 40 Albino rats randomly divided into four equal groups. Group A was the control group and received no intervention. Experimental group B received a topical application of 0.2% sodium fluoride gel. Experimental group C received topical application of stannous fluoride gel 0.4%. Experimental group D received topical application of APF gel (1.23% acidulated phosphate fluoride gel). The different preparations of the gels were applied once daily for 4 minutes on the occlusal surface of the right maxillary molars for 14 days. Salivary pH values were recorded immediately after the application of gels with the help of pH paper on day 1 and day 14. Results: There was a significant difference in the pH level of groups B, C and D after 14 days of fluoride application (p < 0.05). The nonparametric Kruskal Wallis test was applied for the comparison between the groups. Conclusion: This study concluded that all the fluoride gels after administration caused the acidic pH of saliva with the most acidic effect produced by APF gel.