No abstract

Simultaneous quantification of Lopinavir and Ritonavir in tablet by HPTLC method was developed and validated. The chromatograms were developed using a mobile phase of Chloroform: 1, 4 -Dioxane (7:3 %v/v) on pre-coated plate of silica gel GF aluminum TLC plate and quantified by densitometric absorbance mode at 210 nm. The R f value for lopinavir and ritonavir was 0.74 and 0.58 respectively. The linearity of the method was found to be within the concentration range of 160-960 ng/spot for Lopinavir and for Ritonavir, it was 40-240 ng/spot. The lower limits of detection and quantification were 9.56 ng/spot and 28.96 ng/spot for Lopinavir and 6.82 ng/spot and 20.66 ng/spot for Ritonavir. The method was also validated for precision, specificity and recovery. This developed method was used to analyze fixed-dose tablet (Lopimune, Cipla Ltd) sample of Lopinavir and Ritonavir.

No abstract

Wolff-Parkinson-White (WPW) disorder is a disorder where there is additional accessory electrical pathway in the heart. Wolff-Parkinson-White syndrome (WPW) is the commonest form of ventricular pre-excitation. Wolff-Parkinson-White syndrome is not rare in the emergency department. Its early recognition and prompt treatment gives fast restoration to sinus rhythm. Early refer to cardiologist for electrophysiological study is necessary for early diagnosis and needed intervention. The patient with the Wolff-Parkinson-White (WPW) ECG design has much in the same way as patients with different conditions, like, long-QT disorder and Brugada disorder, because in sinus rhythm electrocardiogram (ECG) is different as compared to tachyarrthymic status of the same patient another differential with WPW syndrome will be LGL syndrome where delta wave will be absent