Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat stores with a primary function in the control of lipid reserves,this study aimed to evaluate the influence of hypothyroidisim on serum levels of Leptin,CRP and lipid profile,blood sample was collected from 75 women age ranged between (15-49) years 65 of the them had hypothyroidisim while 10 of the samples were healthy control, The results showed no significant diffirence in serum Leptin (p =0.1),while there was significant high concentration of serum leptin in obeses hypothyroid women in compared to non obeses hypothyroid women Serum Cholesterol ,Triglyceride , VLDL in addition to serum LDL were significantly higher in patient compared to control group,the Serum CRP levels were significantly Higher in hypothyroid patient compared to the control, circulating thyroid hormones do not appear to play a significant effect on Leptin Levels in patients with hypothyroidisim While it Causes Dyslipidemia,with a significant increase in the serum levels of CRP as an inflamantory marker linked between hypothyroidism and risk factors of cardiovascular events.

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Thyroid diseases are among the commonest endocrine disorders. It effects growth, embryonic development, reproduction, tissue differentiation, maturation and  metabolism, this research aimed  to study gonadal dysfunction in hypothyroid womens, included serum levels of  FSH, LH, prolactin, Ferritin and Vitamin B12 with thyroid hormones,   blood sample was collected from women age ranged between (15-49) years 65 of them had hypothyroidisim and they were under hormonal treatment, while 10 of the samples were healthy control, The results Showed a significant difference in Serum levels of T3, T4, TSH, LH, FSH and Prolactin, while there was a significant decrease in Vitamin B12 Levels (P ≤ 0.027) in hypothyroid patients under hormonal treatment compared to control group, we concluded that  circulation thyroid hormone showed a significant effect of serum levels of LH, FSH, Prolactin and Vitamin B12,While no effects shows on serum ferritin.

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