Aceclofenac is a new generational Non-Steroidal Anti-Inflammatory Drug (NSAID), and is considered a better alternative to the popular painkiller diclofenac, as it overcomes some of the adverse gastrointestinal and cardiac side effects associated with the latter. However, the bioavailability of the drug remains limited due to low aqueous solubility (0.058 µg/mL) and poor dissolution characteristics. Hence, improving its dissolution characteristics is of prime significance in order to establish its optimal therapeutic efficacy. In an effort to tackle this issue, we report the use of novel Soluplus ®-based nanocomposites, prepared from emulsion templates, as effective drug loading agent for aceclofenac. Nanoemulsion templates were prepared by high-shear homogenization using a probe sonicator. The emulsions were subsequently lyophilized to obtain free flowing powders. The amorphization of the drug with increasing polymer content was clearly observed from powder X-ray diffractogram, while the drug-polymer interaction was explored by FTIR spectroscopy. The phase purity and homogeneity of the formulation was characterized using Differential Scanning Calorimetry. The dissolution profiles of the formulations were established by an USP paddle apparatus. Phase solubility study was conducted to evaluate the effect of polymer concentration on aqueous solubility of aceclofenac. The values of Gibbs-free energy (ΔG˚tr) associated with the aqueous solubility of aceclofenac in the presence of Soluplus was used to optimize the polymer content. The in vitro dissolution rates of aceclofenac from the nanoparticles were significantly higher compared to the pure drug. Thus, Soluplus nanoparticles provide promising formulations for the improvement of the dissolution profiles and thus, the bioavailability, of aceclofenac.

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In the present study Nano Calcium-Aluminium mixed oxide material (NCAMO) was synthesized by solution combustion method in 1:1, 1:2, 4:1, 3:2 molar ratios of Calcium and Aluminum nitrates as oxidizers and urea as fuel for an efficient adsorption of fluoride from drinking water.Molar composition of 1:1 ratio was found to exhibit better adsorption properties and the same Downloaded by [University of Birmingham] at 02:47 23 March 2015 A c c e p t e d M a n u s c r i p t 2 was characterized by XRD, FESEM, and FTIR. The optimized conditions for maximum adsorption capacity were achieved at pH4 with contact time of 4 hours by adding 1g/L of NCAMO to initial fluoride concentration of 8mg/L. The sorption of fluoride on NCAMO followed Langmuir isotherm model strongly suggested monolayer adsorption. The calculated equilibrium adsorption capacity 23.7 mg/g of NCAMO strongly suggests the dominance of monolayer adsorption process. The adsorption kinetics was well described by pseudo-second order equation confirming chemisorption.

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The chalcopyrite semiconductors belonging to the I