Nanotechnology is a branch of science and technology relating to the matter on the atomic and molecular scale in the size range between 1-100 nm. Iron nanoparticles have diverse diagnostic and potential therapeutic applications with unique magnetic and catalytic properties and potent biological activities. The present study aimed to analyse the anti-inflammatory activity of iron nanoparticles synthesized from dried ginger. The synthesized iron nanoparticles were characterized using UV-vis spectroscopy and evaluated for anti-inflammatory activity by inhibition of albumin denaturation assay. The nanoparticles showed maximum absorbance at 360 nm and revealed potent anti-inflammatory effect with maximum of 83.5% inhibition at lowest concentration of 50 µl and thus can be used as an anti-inflammatory agent in various inflammatory diseases.