The present study was intended to determine the histological changes induced by Cytarabine drug on the structure of rabbit's livers and the protective effects of vitamin E on these histological changes. The treated group with daily intraperitoneal dose of (50 mg/kg body weight) of Cytarabine alone, showed a massive histological change represented by infiltration of mononuclear inflammatory cells, epithelioid cell and Kupffer's cells in hepatic tissue. Fibrosis in portal area, congestion of blood vessels as well as hyperplasia of bile canaliculi and coagulative necrosis of hepatocytes were also noticed in other sections. While the group that received protective (800 IU of vitamin E) prior to each Cytarabine injection, showed a considerable histological improvement than the group received Cytarabine alone, as the histological sections of this group showed a nearly normal histological architecture of the liver that represented by normal arrangement of hepatic cords, no fibrosis no congested blood vessels were seen. though distension of hepatic sinusoids and coagulative necrosis of some hepatocytes were still observed. The present study suggested that vitamin E is an effective chemo-protective agent against hepatotoxicity when used as a protective agent prior to Cytarabine drug taken.

The present study was designed to determine the histological changes induced by Cytarabine drug on the structure of rabbits kidneys and the protective effects of vitamin E on these histological changes. The treated group with daily intraperitoneal dose of (50 mg/kg body weight) of Cytarabine alone, showed a massive histological changes represented by renal tubular necrosis, glomerular atrophy and enlarged urinary spaces (widening of Bowman's spaces), infiltration of lymphocytes and macrophages within interstitium of the cortex, formation of hyaline cast in some of the tubular lumens as well as fibrosis and hemorrhage in the cortex were also observed. While the group that received a protective (800 IU of vitamin E) prior to each Cytarabine injection showed a significant improvement that represented by focal regions in the cortex with a normal renal tubules except for a cloudy cell swelling which is a reversible injury, also neither cortical hemorrhage nor hyaline cast formation were seen, in addition to presence of focal areas of normal glomeruli. The present study suggests that vitamin E is an effective chemo-protective agent against nephrotoxicity when used prior to each Cytarabine administration.