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Aim The main purpose of this study was to study the preventive effect of Penicillium sp. CX-1 on Phytophthora cactorum causing Salvia miltiorrhiza blight and its positive effect on plant growth. Methods and results The endophytic strain CX-1 was isolated from the medicinal plant Corydalis saxicola Bunting and identified as Penicillium oxalicum. The growth inhibitory capacity of CX-1 against P. cactorum was 74.4% in the strain co-culture test and 86.2% in filtrate-modified plates. In the pot experiment, the in vivo control of CX-1 against P. cactorum in S. miltiorrhiza was 36.0%, which was higher than that of an anti-Phytophthora fungicide (23.4%). In addition, CX-1 had a potent ability to solubilize phosphate and also showed the ability to produce the plant hormone indole-3-acetic acid (IAA) and siderophores, which increase the bioavailability of iron to plants. It was demonstrated through pot experiments that CX-1 could significantly promote plant growth. As determined by real-time quantitative PCR, the expression of some S. miltiorrhiza tanshinone-related biosynthesis genes were significantly upregulated following colonization by CX-1. Conclusion Strain CX-1 could effectively inhibit P. cactorum, the causative agent of S. miltiorrhiza blight, and significantly promoted the growth of plant through several different routes.

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BACKGROUND: In recent decades, illicit drug testing has become a high priority area in law enforcement and forensic analysis. OBJECTIVE: Since patents are the largest source of technical information in the world, patent database analysis for illicit drug testing is extremely important to effectively promote the development and protection of the related intellectual property rights. METHODS: In the present study, we first retrieve a database of 1732 drug detection patents using keywords and logical expressions related to the title, abstract, and claims, and subsequently discuss the current global patent statistics in detail. RESULTS: The relevant patent information is presented, including patent application quantity, filing country, ownership, and technical field. CONCLUSIONS: Finally, we summarize the current development trend in drug testing and propose several suggestions focused on the bottleneck of analytical techniques.

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