Coronavirus disease 2019 (COVID-19) is one of the respiratory system diseases with unknown etiology and clinical characteristics. Defects in the liver and kidneys appear to be common in Covid-19 patients. Aspartate transaminase (AST) enzyme, Urea, creatinine, and Alanine Aminotransferase (ALT) enzyme levels are frequently exalted at the start or within the infection. This pretext suggests that Covid-19 interferes with the functions of the liver and kidneys. The current study was aimed to estimate the biochemical biomarkers changes that related to liver and kidney functions, such as ALT, AST, urea, and creatinine, in infected patients. 50 patients were diagnosed with infected between May 1 and 1 August 2020, in Dayala Hospital. 100 samples included 50 control and 50 infected were carried out to evalute the level of biochemical biomarkers (the plasma urea, creatinine, ALT and AST).The results showed increased of ALT, AST, BUN and creatinine levels in the infected samples compare with the control samples. The mean serum kidney parameter (Urea, creatinine ) levels were 57.84±10.46, 1.61±0.18respectively, while the mean value of serum liver enzyme (AST, ALT) levels were  41.94±4.59 and 42.54±4.45, respectively, with high significant different (P<0.001) with control healthy group.