No abstract

Purpose: To perform linkage analysis of candidate loci in a large Midwestern family with autosomal dominant essential tremor. Methods: Thirty-eight members of a six-generation family were evaluated for essential tremor using consensus criteria. Linkage analysis was performed with microsatellite markers reported for three genetic loci associated with familial essential tremor. Results: Patients exhibited a combination of postural and kinetic tremor involving primarily the arms and hands, with a mean age of onset of 31 years. Genetic studies excluded linkage to ETM1 and ETM2 loci, as well as a candidate locus for parkinsonism and postural tremor on chromosome 4p. Conclusion: Familial essential tremor is a common hereditary movement disorder demonstrating phenotypic variability and genetic heterogeneity. Genetics in Medicine, 2001:3(3):197-199.

No abstract

Background Corona Virus Disease 2019 (COVID-19) cases continue to increase around the World. Typical symptoms include fever and respiratory illness but a constellation of multisystem involvement including central nervous system (CNS) and peripheral nervous system (PNS) have been reported with COVID-19. Acute ischemic strokes (AIS) have also been reported as a complication. Methodology We analyzed patient characteristics, clinical outcomes, laboratory results and imaging results of four patients with COVID-19 who had AIS. Results All four patients were =< 60 years , had hypoxemic respiratory failure secondary to pneumonia, elevated D-dimer and inflammatory markers. Conclusion Ischemic strokes are known complications in patients with severe COVID-19.