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Retinal images play a crucial role in the clinical diagnosis and detection of many eye diseases. However, the retinal image is degraded with noise and suffers from low contrast, which makes it difficult to interpret the image precisely and accurately. So retinal image enhancement becomes a vital step before any further processing. Here, a new approach is suggested for fundus image enhancement, where the image is processed in the spatial domain through an optimal statistical feature‐based transformation function (SFTF). The proposed SFTF has four tunable parameters. An optimal set of these parameters is obtained through a newly suggested adaptive enhanced leader particle swarm optimization technique. The suggested method is investigated with freely accessible DRIVE, STARE, and IDRiD databases. The efficiency of the suggested technique is assessed through different validation indices. The results reveal superior performance compared with other popular methods used for vessel enhancement.

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