Primary lymphoma concurrent with teratoma of the ovary is exceedingly rare. Based on our review of the literature, there are only 8 case reports describing concurrent primary diffuse large B-cell lymphoma and teratoma. Here, we report the first case of primary follicular lymphoma concurrent with mature ovarian cystic teratoma, which, to our knowledge, has not been described in the literature.
Background and Objectives
Reducing the maximum red blood cell (RBC) shelf‐life is under consideration due to potential negative effects of older blood. An assessment of the impacts of this change on blood supply chain management is evaluated.
Materials and Methods
We performed a simulation study using data from 2017 to 2018 to estimate the outdate rate (ODR), STAT order and non‐group‐specific RBC transfusion at two Canadian health authorities (HAs).
Results
Shortening shelf‐life from 42 to 35 and 28 days led to the following: ODRs (in percentage) in both HAs increased from 0.52% (95% confidence interval [CI] 0.50–0.54) to 1.32% (95% CI 1.26–1.38) and 5.47% (95% CI 5.34–5.60), respectively (p < 0.05). The estimated yearly median of outdated RBCs increased from 220 (interquartile range [IQR] 199–242) to 549 (IQR 530–576) and 2422 (IQR 2308–2470), respectively (p < 0.05). The median number of outdated redistributed units increased from 152 (IQR 136–168) to 356 (IQR 331–369) and 1644 (IQR 1591–1741), respectively (p < 0.05). The majority of outdated RBC units were from redistributed units rather than units ordered from the blood supplier.
The estimated weekly mean STAT orders increased from 11.4 (95% CI 11.2–11.5) to 14.1 (95% CI 13.1–14.3) and 20.9 (95% CI 20.6–21.1), respectively (p < 0.001). The non‐group‐specific RBC transfusion rate increased from 4.7% (95% CI 4.6–4.8) to 8.1% (95% CI 7.9–8.3) and 15.6% (95% CI 15.3–16.4), respectively (p < 0.001). Changes in ordering schedules, decreased inventory levels and fresher blood received simulated minimally mitigated these impacts.
Conclusion
Decreasing RBC shelf‐life negatively impacted RBC inventory management, including increasing RBC outdating and STAT orders, which supply modifications minimally mitigate.
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