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The objective of this study is to evaluate the antioxidant and hepatoprotective activity of aerial part and seeds of Coriandrum sativum plant against Lambda cyhalothrin insecticide.  Male Wistar Albinos rats were randomly divided into control, LCT, CsA, CsS, CsS+LCT, CsA+LCT groups, after 90 days of treatments Biochemical, some oxidative stress parameters, and histopathology of liver tissue were evaluated. Total polyphenol content in aerial part and the seed extract estimated at 9.29 and 14.64 mg EAG / mg of extract and IC50 for an antioxidant activity equal to 19.38 and 22.62 mg/ml respectively. The obtained results revealed that rats received Lambda cyhalothrin insecticide showed a significant change in enzymes activity (AST, ALT, ALP and c-GT) and Glutathione (GSH) in liver. Meanwhile content of hepatic Malondialdehyde (MDA). Histopathology examination of liver revealed that Coriandrum sativum attenuate the incidence of liver lesions triggered by Lambda cyhalothrin intoxication. Therefore, the results of this study show that Coriandrum sativum can be proposed to protect the liver against Lambda cyhalothrin induced oxidative damage in rats, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenging effect. Keywords: hepatoprotective, antioxidant, Coriandrum sativum L., Lambda cyhalothrin, Oxidative stress.

Diabetes mellitus is a chronic metabolic disease. Traditional medicines are currently still popular as an alternative in the treatment of this disease. However, the mechanism of action in lowering blood sugar of most folk recipes remains unproven. The objective of this study is to evaluate the antidiabetic potential of an Algerian halophyte in regulating postprandial hyperglycemia via α-amylase inhibitory activity. For this, methanolic and aqueous crude extracts were prepared from the aerial part of Haloxylon scoparium Pomel and analyzed by HPLC/ UV method. Total flavonoids, total tannins and total alkaloids as specific extracts were also prepared from the same part. The in vitro α-amylase inhibition assay using starch-iodine was performed. As results, the methanolic crude extract seems to be the best with 29 phenolic compounds of which the most abundant is gallic acid. All tested extracts showed better α-amylase inhibitory activities. Among these extracts and compared to acarbose (IC50 = 17.96 µg/ mL), the methanolic crude extract had the highest inhibitory activity (IC50 = 22.9 µg/ mL), followed by total flavonoids and alkaloids. Finally, we conclude that Haloxylon scoparium aerial part had displayed maximum inhibition against αamylase enzyme especially with its methanolic crude extract. It can be used for management of postprandial hyperglycemia with lesser side effects and provide a strong rationale for further animal and clinical studies.

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