No abstract

Summary: The effects of administration of ambilhar to rats poisoned with mercury for two weeks were investigated. The results showed that administration of ambilhar to rats dosed with mercuric Chloride, resulted in a significant increase in the faecal excretion of mercury. At the same time a significant decrease in the urinary Output of the metal was found. Chelation of ambilhar with mercury to form a polar complex with a higher molecular weight could explain its biliary rather than its urinary excretion. The spectral studies of ambilhar and its two mercury complexes prepared in vitro support the possibility that Stimulation of mercury excretion in bile results from the complexation of mercury by ambilhar in vivo. Wirkung von Ambilhar auf die Mobilisierung von Quecksilber und seine Ausscheidung mit der GalleZusammenfassung: Die Wirkung von Ambilhar auf Ratten, die zwei Wochen lang eine Quecksilberchlorid enthaltende Diät erhielten, wurde untersucht. Die Behandlung mit Ambilhar bewirkte einen signifikanten Anstieg der Quecksilberausscheidung in den Faeces, Gleichzeitig fiel die Ausscheidung von Quecksilber im Harn. Die Chelatbildung von Quecksilber mit Ambilhar zu einem polaren Komplex mit höherem Molekulargewicht könnte die bevorzugte Ausscheidung über die Galle gegenüber der mit dem Harn erklären. Spektrophotometrische Untersuchungen von Ambilhar und seiner zwei in vitro präparierten Quecksilberkomplexe unterstützen die Möglichkeit, daß die Quecksilberausscheidung mit der Galle durch Komplexbildung von Quecksilber mit Ambilhar in vivo gefördert wird.

No abstract

Statins (3-hydroxy-3-methyl glutaryl-CO A reductase inhibitors) exert favorable effects on lipoprotein metabolism but may, also, possess antioxidant and antisecretory effects which have led to the interest in the use of that class of drugs outside treatment of cardiovascular diseases. Here, the effects of atorvastatin in experimently induced gastric acid secretion and ulcer formation and the mechanisms underlying that protection in rats were explored. Animals were randomly assigned to three experimental groups (control, indomethacin, and indomethacin+atorvastatin groups). Pyloric ligation was performed for collection of gastric juice, and gastric ulceration was induced by a single intraperitoneal injection of indomethacin (40mg/kg).The following parameters were assayed (volume of gastric secretion and acidity, the level of mucus, and proteolytic activity in gastric juice; lipid peroxides (MDA), nitric oxide (NO), and prostaglandin E 2 (PGE 2 ) in gastric mucosa). Pretreatment with atorvastatin (10 mg/kg orally for 7 days) caused significant reduction in gastric mucosal lesions, MDA and gastric acid secretion associated with significant increase in gastric juice mucin secretion. Also, atorvastatin significantly increased gastric NO and PGE 2 levels. These data illustrate the gastroprotective effects of atorvastatin which may be mediated by its anti-oxidant and anti-secretory properties.

Background: To investigate the relationship between ascorbic acid level in serum and anti-oxidant parameters in blood with type 2 diabetes mellitus patients. Patients and methods: The study was conducted on 85 subjects, 25 as a control and 60 with type 2 diabetes. Results: The current study was done in the period between January 2016-December 2018.The study included 60 patients with type 2 DM. The duration of diabetes ranged from one month to240 month with mean 74.2±64.8. Conclusion: T2-DM patients with more severe diabetic nephropathy had lower vitamin C levels