Amyloidosis is a disease characterized by extracellular accumulation of protein in fibrillary structure (amyloid protein) in various organs and soft tissues. Although the involvement of respiratory system is encountered in systemic amyloidosis, localized pulmonary amyloidosis has rarely been reported. The radiologic findings are nonspecific and show variations according to involvement pattern of amyloidosis. Here we present a 62-year-old female diagnosed as pulmonary nodular amyloidosis with the help of relevant literature.

Background: This experimental study aims to investigate the pleurodesis effects of iodopovidone at different concentrations (2% and 4%) and sterile talc in a rat model. Methods: Forty male Wistar Albino rats were randomly divided into four equal groups including 10 rats in each group. Groups 1, 2, and 3 were designed as the study, and Group 4 as the control group. In Group 1, 4 g sterile talc was given in the slurry form at 20 mL 0.9% saline solution, in Group 2 and Group 3 10% iodopovidone solution were given at 4% and 2% concentrations, respectively, and in Group 4, 0.9% saline was only administrated as 3 mL into the pleural space. All rats were sacrificed on Day 30 and evaluated for macroscopic and microscopic examination. Microscopic evaluation was performed for alveolar collapse, alveolar hemorrhage, alveolar infiltration and fibrosis. Brain, liver, and kidney tissues were also examined. Results: Iodopovidone macroscopically caused a significant adhesion similar to sterile talc at a concentration of 4%. The pleurodesis effect of iodopovidone at a concentration of 4% was significantly similar to talc, when microscopic parameters were evaluated. Granulomas due to sterile talc were observed in the opposite hemithorax. Brain, liver, and kidney examinations revealed no systemic distribution for both agents. Conclusion: Iodopovidone is a powerful alternative to sterile talc with its easy accessibility and low cost. In this study, 4% iodopovidone was found to provide effective and safe pleurodesis in rats. We believe that the use of this concentration in clinical studies would provide more effective results.

Fibröz Displazi fibroosseöz dokunun medüller kemiğin yerini aldığı, özellikle kraniyofasiyal kemikler, uzun tübüler kemikler ve kosta tutulumu gösteren benign karakterde bir lezyondur. Bu olgu sunumunda 64 yaşında asemptomatik hastada malign dönüşüm ihtimali, kotta destrüksiyona ve patolojik kırıklara yol açabilme potansiyeli nedeniyle en bloc rezeksiyon uygulanan bir hastayı literatür eşliğinde sunduk.