Background: Liver is the site of many diseases, many of which become symptomatic wh ile some are diagnosed only on autopsy. Involvement of liver is secondary to cardiac, metabolic, social problem like alcoholism, drug toxicity, injudicious use of topical applications, herbal remedies and environ mental exposures. Ai ms and Objecti ves: In apparently healthy individuals autopsy study sometimes reveals liver diseases. Hence this study aims at finding the frequency and the histopathological appearances in random liver autopsy, so as to evoke public awareness against alcoholis m, drug to xicity and potential toxins (perfu mes, shampoo, cleaning solvents, pesticides fertilizers,). Materials and Methods: The present study was carried out in the Depart ment of Pathology & Depart ment of Forensic Medicine and Toxicology, VIMSAR, Burla, Odisha over a period of 2 years. The liver specimens collected fro m 64 cases were examined grossly as well as microscopically to establish the presence of liver d iseases and also to find out the types of liver d iseases. Results: Out of 64 specimens, fatty change, chronic venous congestion, hepatitis, cirrhosis, Steatohepatitis, and drug toxicity cases are reported; fatty change being the predominant finding. Liver d iseases predominated in males with male to female ratio of 5:1. Conclusion: Autopsy examination of liver was very helpful to identify silent liver diseases.

Background: Breast cancer is the second most common cancer in the world and,by far,the most frequent cancer among women with an estimated 1.67 million new cancer cases diagnosed in 2012. It is well established that there are at least 4 main molecular subtypes of breast cancer based on different patterns of gene expression, and they have a considerable impact on outcome. Objective of this study is to establish a comparative analysis of breast cancer by IHC assay in western Odisha and to correlate with reference to tumor sizes, histological grade and lymph node involvement. Methods: This study was conducted in VIMSAR, Burla, Odisha from July 2014 to August 2017 where 66 Cases of radical mastectomy received for routine histopathological evaluation from Dept of Surgery for histological typing and evaluation of IHC status by Dako Envision TM FLEX/HRP detection reagent. ER, PR, Her2neu and Ki67 were evaluated as per ASCO/CAP guidelines. The molecular subtypes were correlated with known prognostic markers as tumor size,histologic grade and lymph node status. Results: Triple negative and Her2neu 20.9% of cases were more aggressive and correlated with increased tumor size,higher grade and majority showed lymph node involvement at an early stage. Conclusion: After overall assessment it was seen that majority of cases were Luminal A type followed by triple negative and Her2neu positive cases indicating not only the latter are related to poor outcome but also showed its increased prevalence in this part of odisha possibly because of late presentation. Molecular typing help categorize and plan targeted therapy to patients.

Solitary fibrous tumor represents a spectrum of mesenchymal tumors encompassing tumors previously termed haemangiopericytoma, which are classified as having intermediate biological potential in the 2002 WHO classification scheme. The most common site of occurrence is pleura. Abdominal localization is quite rare. We report a case of extraplural site of occurrence of solitary fibrous tumor in the posterior rectus sheath of a 45 year old male patient. The patient presented with a hypogastric midline swelling since one month. Intraope rative finding revealed a mass attached to the posterior rectus sheath. Histopathology revealed oval to spindle tumor cells having round to oval vesicular nuclei, nuclear pleomorphism with moderate mitotic activity; morphologically mimicking Extragastrointestinal stromal tumor .Immunohistochemical staining and FISH studies were performed. The results of IHC staining are given in Table 1 and in figure3. The term Solitary fibrous tumor is favored by soft tissue pathologist to describe a rare heterogenous group of benign & malignant neoplasm along a morphologic continuum. We have described a rare case of malignant solitary fibrous tumor of rectus sheath.