Undeveloped teeth are defenseless against infections, trauma and abnormal anatomies. Apexification has been considered as the standard treatment of immature permanent immature teeth that have suffered from irreversible pulpitis. This course of action boosts the shaping of an apical blockade to intercept the connection between the root canal and, the periodontal surroundings. In spite of that, these techniques have been unsuccessful in achieving root development which may expose the teeth to major side effects such as fractures. Recently, the most favorable therapy for immature or mature teeth with pulp necrosis is the regenerative endodontic treatment. This paper defines the biotic foundation and clinical regenerative endodontic processes currently used in dental practice.